Wolf-Hirschhorn syndrome (WHS) is a rare genetic disorder caused by the loss of a piece on the short arm of chromosome 4 (4p deletion). It is one of the so-called microdeletion syndromes.

Children with WHS often have typical external features such as a narrow face with a high forehead and broad nasal bridge, which is described as a "Greek helmet". Growth and failure to thrive, mental and motor developmental delays and epileptic seizures are common. Malformations of internal organs, such as the heart or kidneys, can also occur.

The severity of the symptoms varies greatly. With good medical care, therapies and aids, many children can make progress and improve their quality of life.