Rett syndrome is a rare genetic disorder that occurs predominantly in girls and usually becomes apparent in the first year of life. After an initial apparently normal development, the affected children gradually lose acquired skills such as speech, hand use and motor skills. Typical characteristics are abnormal, stereotypical hand movements (e.g. hand wringing or rubbing), motor development delays, balance disorders and epileptic seizures.

In addition, breathing problems, sleep disorders, speech and swallowing difficulties and changes in the cardiovascular system can occur. Many children need support with mobility, communication and everyday life. Special aids such as wheelchairs, communication devices or adaptations for everyday life can significantly improve quality of life.